Damian H. Kotsis, Ph.D.

Dr. Kotsis’ practice is concentrated on preparing and prosecuting national and international patent applications in life sciences and chemistry.
 

Throughout his undergraduate and graduate studies, Dr. Kotsis performed research concerning de novo pyrimidine biosynthesis in normal and neoplastic breast cells (WSU), ATP induced nitric oxide release form endothelial cells lining fused silica microbore tubing (SLU) and ryanodine binding to calcium channels in skeletal muscle sarcoplasmic reticula (MSU). He has published his results in peer-reviewed journals and presented his data at national and international conferences. Dr. Kotsis began law school at night while finishing his doctorate during the day and graduated in the top 10% of his law school class.
 

Education

J.D., cum laude, University of Detroit Mercy, 2010
Ph.D. in Biochemistry and Molecular Biology, Wayne State University, 2010
M.S. in Chemistry, St. Louis University, 2002
B.S. in Biochemistry, Michigan State University, 1999

Honors & Distinctions

• Dean’s Honor Society – University of Detroit Mercy
• Dean’s Scholarship – University of Detroit Mercy
• Justice Frank Murphy Honor Society – University of Detroit Mercy
• Graduate Students Academic and Research Award – Wayne State University
• Rumble Fellowship – Wayne State University
   

Professional Affiliations

• American Bar Association
• American Intellectual Property Law Association
• Michigan Intellectual Property Law Association
• American Association for the Advancement of Science
• American Chemical Society
• Alpha Sigma Nu
   

Publications

• Ph.D. dissertation: Regulation of De Novo Pyrimidine Biosynthesis by CAD and CTP Synthetase
• M.S. thesis: Detection of Nitric Oxide in a Biomimetic Circulatory Vessel 

Articles

• Protein kinase C modulates the up-regulation of the pyrimidine biosynthetic complex, CAD by MAP kinase (2007) Front. Biosci. 12, 3892-3898
• Protein kinase A phosphorylation of the multifunctional protein CAD antagonizes activation by the MAP kinase cascade (2007) Mol. Cell. Biochem. 301(1-2), 69-81
• Nuclear localization and mitogen-activated protein kinase phosphorylation of the multifunctional protein CAD (2005) J. Biol. Chem. 280, 25611-25620
• Cell cycle dependent regulation of pyrimidine biosynthesis (2003) J. Biol. Chem. 278, 3403-3409
• Detection of ATP-induced nitric oxide in a biomimetic circulatory vessel containing an immobilized endothelium (2003) Anal. Chem. 75, 145-151
• Flow based amperometric detection of dopamine in an immobilized cell reactor (2003) J. Neurosci. Meth. 124, 129-134
• A quantitative examination of some analytes involved in the control of pulmonary resistance by employing various microflow techniques and novel bio-reactors (2003) Rev. Anal. Chem. 4(22), 235-253