Mark A. Frentrup, Ph.D.

Principal / Detroit Metro Office

Dr. Mark Frentrup joined the Firm after an 18 year career in industrial research. Mark’s practice includes preparing and prosecuting pioneering patents, as well as opinions in support of his clients’ commercial strategies. Mark’s clearance and invalidity opinions reflect an expert level of rigorous technical and legal analysis. He specializes in a wide variety of chemical and mechanical arts, with a particular focus based on his expertise in organic and polymer chemistry.

Mark is also involved in planning and executing patent strategies that cover his client’s technology with multiple filings. One of his patent families has generated 20 continuations as of this writing. He has written patent portfolios covering technologies that include lithium ion batteries and battery active materials; anticancer drugs; coatings; ultrahigh molecular weight polyethylene for medical implants; sorbent technology for reducing mercury and other emissions from coal burning; nanotechnology; fuel cells; and last but not least, fluorocarbon elastomers for seal applications.

In the polymer area, Mark is expert in synthesis, materials properties and industrial applications of polyurethanes; organic coatings and film forming polymers; polyolefins; natural and synthetic rubber; fluorocarbon thermoplastics and elastomers; thermoplastic elastomers; dispersions; and nonionic surfactants.

Regarding inorganic chemistry, Mark has written and prosecuted patents on lithium ion battery active materials, including new metal oxides and phosphates, as well as novel carbothermal methods of synthesis. He also understands zeolites and heterogeneous catalysts. In organic chemistry, Mark has prepared patent landscaping reports for pharmaceutical active ingredients, as well as supported ANDA filings under the Hatch Waxman Act with paragraph IV certifications, notification letters and opinions assessing the validity of Orange Book patents.

As an undergraduate, Mark spent several summers in synthesis (organic and inorganic) at the University of Texas (including one summer at the campus in Dallas) and Brown University. His synthetic experience includes lithium enolate chemistry, photochemical synthesis, cobalt organometallic synthesis, chromatographic separations and characterization of reaction products using proton nmr.

During the school year, Mark worked in an x-ray crystallography lab, gaining experience in crystal growth, data collection and solution of small molecule structures using both heavy atoms and direct methods. He then served as a biochemistry research fellow (hemoglobin protein crystal structure) at UT Austin before entering graduate school.

While at Michigan State, Mark held a Graduate Fellowship from the National Science Foundation, along with a Quill Foundation Fellowship awarded by the Chemistry Department. His dissertation under Professor A. Tulinsky dealt with determination of enzyme structure and function using x-ray crystallography.


  • Patent Information Users Group


  • German, professional working proficiency
  • French, Russian, Spanish and Italian, limited working proficiency
  • Mark works with a network of foreign patent associates to obtain international patents for clients, where he is assisted by associates with fluency in Chinese, Korean and Japanese


J.D., summa cum laude, Wayne State University, 1999

Ph.D., Chemistry, Michigan State University, 1982

B.S., Chemistry, summa cum laude, University of Texas – Austin, 1976

Bar & Court Admissions


U.S. Patent and Trademark Office